Man Bock Gu’s Biography
Man Bock Gu, Professor & Chair, Department of Biotechnology, Korea University; Director, BK21 PLUS for Biotechnology
Dr. Man Bock Gu is a professor, the department chair, and the director of BK21 PLUS School of Life Sciences and Biotechnology in the Department of Biotechnology at Korea University, Seoul, Rep. of Korea. He received his Ph.D. in Chemical Engineering from the University of Colorado at Boulder, Colorado, USA in 1994, and completed his postdoctoral studies in Chemical Engineering at the University of Delaware, USA in 1995, where he worked on the bioluminescent bacterial biosensors with Dr. Robert LaRossa at DuPont Central Research & Development. He had been a PI of the National Research Lab (NRL) on Biosensors, while he was a professor at Gwangju Institute of Science and Technology (GIST), Gwangju, Rep. of Korea, from 1996 to 2005. Prof. Gu has received a few fellowships and awards, including an Alexander von Humboldt research fellowship, many awards from the Korean Society of Biotechnology and Bioengineering (KSBB), and Prime Minister’s Commendation and Citation Ribbon for Research from Ministry of Science and Technology of Korea. Prof. Gu was a president of Korean Biochip Society in 2014. He is a regular member of Korean Association of Science and Technology (KAST) since 2015. He has edited a few books, authored many book chapters, hold numerous patents, and published more than 200 peer-reviewed papers. His current research interests include the innovations on aptamers, enzymes, and cells with various nano-size materials, nanocomposites, and nanofibers and microbeads for biosensing, imaging, and other applications.
Screening a Pair of Aptamers using GO-SELEX for Nanobiosensors and Lateral Flow Assays
Aptamers are single-stranded nucleic acids having molecular recognition properties similar to antibodies, and isolated by in vitro selection and amplification process, SELEX. This talk will start with how the aptamers are innovatively screened, for the first time in the world, by using a new nano-material, graphene, without the immobilization of targets and how a few aptamer duos, inevitable for being applied in a sandwich-type platform, a reliable platform for commercialization eventually, were successfully develpoed for different pandemic influenza viruses, from graphene oxide-based immobilization-free screening (GO-SELEX). In addition, some examples obtained from the interactions among aptamers, nanoparticles, and targets will be shown for a single or flexible aptamers with their successful implementation to the aptasensors. In addition, the benefits of using nano-sized materials for biosensing applications including lateral flow and SPR assays will be presented with scientifically proven clear examples of different organic-inorganic hybrid forms of nanomaterials and aptamers.