Hidehiro Oana’s Biography

Hidehiro Oana, Associate Professor, The University of Tokyo

Dr. Hidehiro Oana is currently an Associate Professor in the Department of Mechanical Engineering at the University of Tokyo. He received his B.S., M.S. and Ph.D. in applied physics from Nagoya University, Japan. Prior to his current appointment, he was a postdoctoral research fellow of the Japan Society for the Promotion of Science (JSPS) in the Department of Mechanical Engineering at Kyoto University, then, an assistant professor in the Department of Physics at Kyoto University. His present research interests are lab on a chip, analytical chemistry, soft matter physics, with specific focus on developing a single cell analysis technology for epigenomic studies.

Direct Observation of Folding Stability of Individual Chromosomes Isolated From Single Mammalian Cells in a Microfluidic Channel

Chromosomes were isolated from single mammalian cells in a microfluidic channel. Then, the isolated chromosomes were tethered at microstructures and exposed to high-salt solution in the channel. As a result, the chromosomes were unfolded non-uniformly, which can provide insights into epigenetic mechanisms.