Han-Sheng Oswald Chuang’s Biography

Han-Sheng Oswald Chuang, Associate Professor, Department of Biomedical Engineering, National Cheng Kung University

Han-Sheng Chuang is currently an associate professor in the Department of Biomedical Engineering at National Cheng Kung University, Taiwan. Dr. Chuang received his bachelor and master degrees from the Department of Mechanical Engineering at National Cheng Kung University in 1998 and 2000, respectively. He joined Industrial Technology Research Institute (ITRI) as a R&D engineer in 2001. After then, he worked with Professor Steve T. Wereley for advanced microfluidics and received his Ph.D. from the School of Mechanical Engineering at Purdue University in 2010. After graduation, he received an appointment as a postdoctoral researcher at University of Pennsylvania and worked with Professor Haim H. Bau on cell sorting and Caenorhabditis elegan manipulation. In 2005, he was awarded a competitive fellowship from Ministry of Education, Taiwan. He and his research fellows were the finalists of the prestigious Burton D. Morgan Business Competition in 2008 and 2009, respectively. Lately, he received the 2014 Young Researcher Career Grant from the Ministry of Science and Technology, the 2015 Young Scholar Award from the Taiwan Comprehensive University System, and the 2016 Excellent Teaching Award from NCKU. In addition, he is also a cofounder of a US-based start-up, Microfluidic Innovations, since 2009 and an executive director of the Association of Chemical Sensors in Taiwan. Dr. Chuang has dedicated to the field of microfluidics for more than 10 years. His research interests are focused on nano-/micro-fluidics, Bio-MEMS/NEMS, and optical diagnostics.

Saving Lives With Brownian Motion

Sepsis is a fatal infectious disease claiming thousands of lives every year. Antimicrobial susceptibility testing (AST) plays a pivotal role in the success of treatments. However, the turnaround time for the outcome of conventional AST usually requires over 24 hours, resulting in high patient mortality. Moreover, antibiotics abuse can also incubate the booming of superbugs. A reliable and efficient drug screen becomes increasingly important to date to save lives in a timely fashion. To this end, a technique combining optical diffusometry and bead-based immunoassays is developed herein to achieve a rapid quantification of target microorganisms. The limit of detection of the method could achieve 100 CFU/mL. This study provides valuable information to timely treatments against poly-microbial diseases in the near future.